If you know anything about the TV series, "House M.D.", you know that House and Wilson have a very interesting friendship. And if you don't know anything about it, I'll break it down for you: House is a narcissistic, sarcastic, immature diagnostician, and Wilson is a caring, considerate, mature oncologist. They're total opposites of each other, yet they make the best best friend to one another. These types of friendships may only seem possible on TV; however, they can exist in the real world, and although they may be rare, they can be some of the best friendships you'll ever have. In a world where you are a real life Gregory House (like myself), you will need to find your very own James Wilson -- and this is what having a best friend who is the total opposite of you is really like.

1. They have to put up with your immaturity.

And they're not afraid to tell you to grow up every once in a while.

2. You sometimes have to keep them from getting too caught up in their emotions.

No one ever wants to see their best friend too upset, and sometimes all they need is a reality-check from their indifferent bff.

3. Going out together in public is always an interesting time.

One of you is always bound to embarrass the other, but it's always a fun time.

4. You have to cherish them for being one of the few people who can put up with you.

People with similar qualities to yourself may put up with you a bit easier. So you have to appreciate your best friend especially when they are nothing like you.

5. They're constantly trying to bring out your more emotional side.

If anyone is going to get you to open up, it will be your sensitive best friend.

6. You have to get used to over-dramatization.

When sappy sentiments aren't necessarily your thing, you have to adapt to your best friends seemingly over-dramatic thoughts.

7. ...And they have to get used to your harsh remarks.

You'll admit, sometimes you can be a bit rude on occasion. But when you're naturally sarcastic, someone is going to have to get used to it -- and that someone will just have to be your best friend.

8. They keep your attitude in check.

You rely on their kind nature to make sure you aren't being too savage, especially in public.

9. They make you feel things that you may not usually feel.

And if you're going to get emotional over something, it's going to be about them.

10. You can never be mean to them and really mean it.

No matter how much you make fun of them, you never truly mean what you say -- you love them too much for that.

11. You're each other's eternal support system.

Even if you don't always fully understand what the other is going through.

12. You balance each other out, and no differences can keep you apart.

Because you need each other more than you may realize in order to stay sane.

13. But no matter how opposite you two may be, you're always on the same page.

More synchronized than synchronized swimmers.