What Is CRISPR And Why Does It Matter? | The Odyssey Online
Start writing a post
Student Life

What Is CRISPR And Why Does It Matter?

Here comes human genetic engineering!

213
What Is CRISPR And Why Does It Matter?
Business Insider

The invisible plague of genetic disorders has unfairly limited or ended millions of lives before they even start. Genetic disorders are the leading cause of infant mortality in the United States, making them responsible for roughly one in four infant deaths. Half of the mentally disabled population have their genes to thank for their condition. They are given a difficult burden by the arbitrary genetic lottery, and they are not alone. Many people are even morally limited by their genes:

Willingness to commit antisocial acts, including lying, stealing, starting fights, and destroying property, is partly heritable ... Most psychopaths showed signs of malice from the time they were children. They bullied smaller children, tortured animals, lied habitually, and were incapable of empathy or remorse, often despite normal family backgrounds and the best efforts of their distraught parents. Most experts on psychopathy believe that it comes from a genetic predisposition.

As it turns out, "most experts" are right in this case. Psychopathy is about 50% heritable, like most other personality traits. Your genes determine a significant part of who you are without your input.

Genetic engineers have been working for decades to combat genetic disorders and give a better chance to those who have been unfairly punished by nature. But, as it turns out, genetic engineering is hard. Really hard. It is also expensive and time-consuming, which is a huge obstacle for genetic engineers. As Bruce Conklin pointed out, "It was a student's entire thesis to change one gene."

However, within the last five years or so, a revolutionary new gene editing technology emerged which makes gene editing cheaper, faster and easier than ever: "CRISPR-Cas9 editing."

For over 30 years, scientists have been confused by a certain part of DNA in bacteria. The same pattern would occur over and over, alternating with unique ones. They named it "clustered regularly interspaced short palindromic repeats," mercifully shortening this convoluted phrase into the short and catchy acronym "CRISPR."

Recently, scientists realized that these CRISPR patterns matched the DNA of certain viruses. They figured out that the bacteria store virus DNA to identify viruses in the future, like antibodies in our immune system. Cas9 is a protein that cuts DNA wherever RNA tells it to. Normally, this is used so the Cas9 can find and delete any unwanted virus DNA when the same kind of viruses attack in the future. However, scientists have realized that it opens up an incredible opportunity for gene editing:

A system where you can send one protein to cut anywhere in the genome just by giving it a chunk of RNA is really useful for molecular biologists . . . CRISPR lets you make a precise cut in DNA, so you can use it to knock out a gene, or even trick the cell into inserting a gene.

New applications of CRISPR are popping up everywhere as research increases at an exponential rate:

The 2016 point on that graph is zero because that graph is from 2015. Considering that CRISPR editing is a revolutionary step forward in genetic engineering, 2016 is likely to continue the boom in CRISPR research.

Signs of the possibilities that CRISPR opens up for us are only starting to pop up in news headlines. For example, the first few human trials to use CRISPR to treat cancer were approved this year. As CRISPR spreads, it will enable us to combat problems which our ancestors saw as unsolvable or "part of human nature."

Like any of the technologies that have given us an unprecedented amount of power over certain situations, CRISPR is bound to lead to serious ethical debates. Ideally, legal restrictions will make sure that this new technology is only used for the right reasons. But there are plenty of right reasons to use it for, which is likely to give millions of people their lives back after their genes tried to steal them.

For more information on this subject, check out some of the following resources:

Kurz Gesagt: "Genetic Engineering Will Change Everything Forever - CRISPR"

Nature: "CRISPR: Gene Editing is Just the Beginning"

Cody Stewart via Odyssey: "CRISPR: What It Is And Why You Should Care"

The New Yorker: "The Gene Hackers"

Report this Content
This article has not been reviewed by Odyssey HQ and solely reflects the ideas and opinions of the creator.
student sleep
Huffington Post

I think the hardest thing about going away to college is figuring out how to become an adult. Leaving a household where your parents took care of literally everything (thanks, Mom!) and suddenly becoming your own boss is overwhelming. I feel like I'm doing a pretty good job of being a grown-up, but once in awhile I do something that really makes me feel like I'm #adulting. Twenty-somethings know what I'm talking about.

Keep Reading...Show less
school
blogspot

I went to a small high school, like 120-people-in-my-graduating-class small. It definitely had some good and some bad, and if you also went to a small high school, I’m sure you’ll relate to the things that I went through.

1. If something happens, everyone knows about it

Who hooked up with whom at the party? Yeah, heard about that an hour after it happened. You failed a test? Sorry, saw on Twitter last period. Facebook fight or, God forbid, real fight? It was on half the class’ Snapchat story half an hour ago. No matter what you do, someone will know about it.

Keep Reading...Show less
Chandler Bing

I'm assuming that we've all heard of the hit 90's TV series, Friends, right? Who hasn't? Admittedly, I had pretty low expectations when I first started binge watching the show on Netflix, but I quickly became addicted.

Without a doubt, Chandler Bing is the most relatable character, and there isn't an episode where I don't find myself thinking, Yup, Iam definitely the Chandler of my friend group.

Keep Reading...Show less
eye roll

Working with the public can be a job, in and of itself. Some people are just plain rude for no reason. But regardless of how your day is going, always having to be in the best of moods, or at least act like it... right?

1. When a customer wants to return a product, hands you the receipt, where is printed "ALL SALES ARE FINAL" in all caps.

2. Just because you might be having a bad day, and you're in a crappy mood, doesn't make it okay for you to yell at me or be rude to me. I'm a person with feelings, just like you.

3. People refusing to be put on hold when a customer is standing right in front of you. Oh, how I wish I could just hang up on you!

Keep Reading...Show less
blair waldorf
Hercampus.com

RBF, or resting b*tch face, is a serious condition that many people suffer from worldwide. Suffers are often bombarded with daily questions such as "Are you OK?" and "Why are you so mad?" If you have RBF, you've probably had numerous people tell you to "just smile!"

While this question trend can get annoying, there are a couple of pros to having RBF.

Keep Reading...Show less

Subscribe to Our Newsletter

Facebook Comments