1. George Williams and Bree Van de Kamp

George Williams was the Van de Kamp family pharmacist who had a weird love and obsession for Bree. When Bree’s Husband Rex got sick, George intentionally did not give him the right medicine he needed, leading to Rex’s death. After Rex’s death, George and Bree had a relationship. It should have been a red flag when Andrew made him snap or when Bree accidentally shot George’s toe off, but ultimately the relationship finally ended when Bree found out the truth, which George paid the ultimate price for.

2. Gabrielle Solis and Victor Lang

Victor Lang was the Mayor of Fairview and the second husband of Gabrielle Solis. Victor fit all of Gabby’s needs coming from a wealthy family and living a posh lifestyle, but Gabby quickly learned that Victor had his eyes more on climbing the political latter than on her. Eventually cheating on Victor with Carlos, she left him, leading to a heap of mishap and trouble all coming to an end the dreadful day of the Wisteria Lane tornado.

3.  Mike Delfino and Katherine Mayfair

Let's be honest: Mike and Susan were meant to be, so Mike and Katherine pretty much ruined our life while they were together. Our hearts all broke the day Mike decided to move in with Susan's longtime friend and new neighbor, Katherine. Our senses were proved right once they finally broke up and Katherine went nuts thinking she and Mike were still meant to be, even stealing Susan's wedding dress and crashing her and Mike's wedding.

4. Edie Britt and Dave Williams

Something was fishy from the second Dave Williams stepped onto Wisteria Lane and threatened an old man for his house. Though Dave did his best to hide his past and the problems he faced, the truth started to surface. We all knew it was time for Dave to go when he started the fire at the bar, but especially when he put poor innocent M.J. Delfino's life in jeopardy. Poor Edie, she never caught a break.

5. Tom Scavo and Jane Carlson

If there was a power couple on Wisteria Lane, it would be Tom and Lynette. So when they decided to separate, our world was shattered along with the hope that true love lasts. Jane wrecked Lynette's life and ours, making us scream at our TVs with anger. But much to our happiness Tom realized his lasting love for Lynette and finally came to his senses leaving Jane to go wreck the life of someone else.