Anyone that watches Grey's Anatomy knows about the pain that I am referencing. Here's a list of 10 of the most heartbreaking moments with links to the scenes so you can re-experience the pain. Get your tissues ready.
Derek Shepherd's death
Season 11, Episode 21: How To Save A Life
"Derek.. it's okay. You go. We'll be fine."
Oh, but we weren't fine. And I think I can speak for everyone when I say I'm still not fine.
"DOUBLE-O 7"
Season 5, Episode 22: Now or Never
The only positive side to this episode was that he was trying to save a woman's life.
We still miss you George O'Malley.
Dr. Burke leaving Christina Yang at the altar
Season 3, Episode 25: Didn't We Almost Have It All
Didn't we almost have a happy ending? No. Shonda doesn't want us to be happy.
Denny Duquette's heart failure
Season 2, Episode 27: Losing My Religion
He could've taken my heart and maybe I wouldn't be crying right now.
Lexie's death
Season 8, Episode 24: Flight
Nope. I'm still not ready to talk about it.
...Then Mark's death
Season 9, Episode 1: Going, Going, Gone.
Okay, really? He had to die the episode right after Lexie dies? Like that wasn't enough? Heartless, Shonda. Just heartless.
The death of April and Jackson's baby
Season 11, Episode 11: All I Could Do Was Cry
The title of the episode explains everything.
Henry is dead
Season 8, Episode 9: Dark Was The Night
And dark was my soul.
Meredith and Cristina saying goodbye
Season 10, Episode 24: Fear (of the Unknown)
Meredith and Cristina say goodbye
Shonda, please just bring Cristina back.
The hospital shooter
Season 6, Episode 23: Sanctuary
Derek and Karev get shot, Meredith has a miscarriage, and Cristina has a gone to her head while she tries to save Derek's life. There was so much that happened in this episode that I'm surprised my heart is still functioning.