MIT Students Using DNA To Treat Endometriosis | The Odyssey Online
Start writing a post
Student Life

MIT Students Using DNA To Treat Endometriosis

152
MIT Students Using DNA To Treat Endometriosis
Brian Teague

This summer, 12 MIT students are working on a project to create a treatment for endometriosis in the form of a genetic circuit. In late October, they will present the completed project to the over 300 teams from around the world participating in the International Genetically Engineered Machines (iGEM) competition at the Hynes Convention Center.

In the past, MIT iGEM teams have addressed Alzheimer's disease, cell differentiation and biodiesel production, but this year the team is bringing synthetic biology into the world of women's health. Endometriosis, the topic of the MIT iGEM team's research, is a condition characterized by extreme pelvic and abdominal pain, and it affects one in 10 women in the USA, including public figures like "Star Wars" actress, Daisy Ridley, Secretary of State Hillary Clinton and others.

Despite being almost commonplace, it's only relatively recently that endometriosis has become a focus of medical research. The pain is caused by cells from the uterine lining, called the endometrium, growing elsewhere in the body. These abnormal growths of endometrial cells can be large or small, and in the past, small growths could not be sensed. Back then, before endometriosis was a possible diagnosis, many women complaining of pain with no obvious or medically diagnosable cause would be carted away to asylums, labeled as "hysterical." Even today, although great strides are being made in understanding endometriosis on the molecular level, the treatment options for women with endometriosis are bleak. Pain medications and hormone therapy may minimize the symptoms of the disease, but they do nothing to get rid of the out-of-place endometrial cells causing the pain, and hormone therapy, in particular, can have noticeable and unpleasant side effects. The only options to actually remove the endometriosis are by undergoing surgery, either conservatively removing only the endometriosis cells (in minor cases) or by getting a hysterectomy, which is the removal of the uterus, cervix and ovaries (in extreme and recurrent cases).

After learning of this disheartening set of options for women with endometriosis, the MIT iGEM team set out to create an alternative. The team is working in the Weiss Lab at MIT, in the university's Synthetic Biology Center. Synthetic biology is a form of biological engineering that characterizes and uses standardized parts to make some product. These parts may be proteins, which are large molecules in a cell that perform some function like sense a hormone or read DNA, or RNA, a single-helix counterpart of DNA that brings messages around the cell, or they may be stretches of DNA code with which RNA or proteins can somehow interact. Once researchers begin putting these pieces together, the possibilities are endless, making synthetic biology a new and exciting field of biological research.

Over the next few months, the MIT iGEM team will create a genetic circuit built from these biological parts. The circuit will be made of DNA and protein components to sense conditions in the cell, while using Boolean logic, a system that relies on binary assumptions that some condition is either "on" or "off," analogous to 1 or 0, to create an output. The MIT iGEM team's goal is to create a circuit that will first recognize when it's in an endometriosis cell and then produce some output, like causing the cell to die, thus removing the endometriosis without requiring surgery. The circuit could also result in the endometriosis cell producing some chemical that can be sensed through a blood or urine test, as a noninvasive and accurate alternative to the only current sure way to diagnose endometriosis: laparoscopy.

On Monday, June 13, the team will meet with experts in the field including Asgi Fazleablas and Linda Griffith to present their circuit design and seek feedback.

Report this Content
This article has not been reviewed by Odyssey HQ and solely reflects the ideas and opinions of the creator.
Student Life

7 Jobs Your Roommate Has

She's got your back with everything that college throws at you.

600
Cristina Yang and Meredith Grey in scrubs sit against a wall, smiling and enjoying a break.

If you are anything like my roommate and I, you have a friendship with your roomie. You’re lucky to have gotten a roommate that is easy to get along with and more importantly cool to live with. Whether you found her on Facebook or went random, a roommate is a big part of life in college. This list goes through some of the jobs that a roommate has that help you get through college.

Keep Reading...Show less
Student Life

35 Things I Wish I Learned In My Freshman Year Of College

Just some relatable college student advice! Yes, you aren’t the only one!

746
Towson University
YouTube

Freshman year can either be the greatest year, or the roughest year. It depends on your transition and how you adjust. For me, freshman year in college was one of the best years of my life. However, looking back, there are a few things that I wish I learned.

Now that I am a sophomore, I can finally do things a little differently. Here are a few things that I wish I learned my freshman year of college!

Keep Reading...Show less
Woman in field with a red heart-shaped balloon under a colorful sky.

Being single can be great and awful at the same time. Yeah, it's awesome to have time to yourself to figure out who you are and make your own decisions. It would also be nice to have someone to go through life with, but it needs to be the right person. I haven't found that person yet and here's a few reasons why.

Keep Reading...Show less
Entertainment

15 Times "Parks and Recreation" Summed Up Your Library Experience

"I've only slept nine hours over the past four days, so I'm right on the verge of a nervous breakdown." - Leslie Knope

5794
Parks and Recreation excitedly gathered around a laptop at a table in an office setting.

The library. Club lib. The place every college student goes when they want to try and be a productive member of society. Who better to explain your experience than Parks and Rec?

1. When you've finally found the energy to leave your dorm room and walk into the lib like

Keep Reading...Show less
Taylor Swift in orange dress playing a moss-covered piano on stage with bright lights.

A three-and-a-half-hour runtime. Nine Eras. Eleven outfit changes. Three surprise songs. Zero breaks. One unforgettable evening. In the past century, no other performer has put on an electric performance quite like Taylor Swift, surpassing her fans ‘wildest dreams’. It is the reason supporters keep coming back to her shows each year. Days later, I’m still in awe of the spectacle ‘Miss Americana’ puts on every few days in a new city. And, like one of Taylor’s exes, has me smiling as I reminisce about the memories of the night we spent together.

Keep Reading...Show less

Subscribe to Our Newsletter

Facebook Comments