1. Saying then instead of than, or vice versa.
I watched "Grey's Anatomy" then I did my homework. I would rather watch "Grey's" than do my homework. "Then" is generally showing when something happened, whereas "than" is comparing.
2. Mixing up lose and loose.
I always lose my car keys. The shirt was too loose to fit me. If you lose it, then it's lost. You can't find it. If something is loose, it's not fixed in place. Loose is the opposite of tight.
3. "I could care less."
So then why don't you? If you could care less, that means you care a little. Like on a caring scale of 1-10, you're at least a 2 and could be at 10. It's possible for you to care less. What you probably mean to say is "I couldn't care less." You do not care a bit in the world, and it is physically impossible for a person to care even less than you do. You're at a 1 on the scale, or even a zero on the scale. You broke the scale because that's how much you don't care.
4. Spelling definitely as "defiantly"
Yes, definitely is one of the more difficult words to spell in the English language. I guess. However, if you're definitely doing something then you're 100% positive you're going to do it. If you're defiantly going to do something that means you're doing something rebelliously.
5. There, their, and they're
"I went over there to see their new house, and they're already repainting." There is a location. Their is a possessive, it belongs to them. They're is simply they are.
6. To, too, and two
"I went to the store for two apples. She came, too." Two is the number 2. Too means also. To is pretty much everything else.
7. Your and You're
I don't know how people don't know this. Your is possessive, while you're means you are. You're is a contraction. Contractions connect two words. If you mean to say you are great then it's you're great. If you mean to say the pumpkin belongs to you, then it's your pumpkin. It's seriously so simple.