Grey's Anatomy is a show that has been with us since 2005. It is a beautiful drama full of relatable characters and good stories. It's totally worth any binge watching that may happen involving the series, even if series sometimes characters die, as with all good series. And so with that in mind here are twelve of the most painful deaths to occur in Grey's Anatomy, so be prepared to cry. Also on a side note, there are some spoilers here!!!

1. George O'Malley

George was one of the best characters and his death truly hurt. No one can forget how they held their breath during this episode.

2. Mary Portman

Mary's death was just cruel, I mean she survived the shooting only to slip into a coma after a routine surgery.

3. Dylan Young

AKA The Bomb Squad Guy, I mean he wasn't the most likeable character but what he did for Meredith by talking to her and keeping her from moving her hand which ultimately saved her life. His death definitely made a lot of people gasp.

4. Charles Percy

No one can ever forget his death as Bailey cried and tried her best to take care of him with the help of their patient Mary.

5. Mark Sloan

Mark was that character that was only likeable after looking at him for a long time and once we did get to like him our days with him were numbered.

6. Lexie Grey

The death of Lexie was truly tragic, especially when we never got to see her and Mark together and happy again.

7. Henry Burton

Seriously this death was not needed and Teddy deserved to be happy.

8. Denny Duquette Jr.

Denny was a tragic death and honestly the character was so well loved that he makes appearances in the show several times after his death which only makes us love him more.

9. Doc

Meredith didn't deserve for her dog to die, he might have driven the other interns insane but he was loyal to her.

10. Derek Shepherd

Derek was with us since the first episode, through tears and laughs. He was the one death that many didn't expect.

11. Bonnie

The sweet girl impaled by a pole in a train accident with another man who couldn’t be saved. So she gave up her life for a stranger.

12. Heather Brooks

The worst thing about Heather's death was it could have been easily avoided, and it honestly came at the worse timing given she had really started to find herself in the medical field.

So there you have twelve of the most painful and tragic deaths to have taken place during Grey's Anatomy, and while more names could have been added to the list, we then would have had to mention any character who died in the show.